Time to Insulin Initiation Cannot Be Used in Defining Latent Autoimmune Diabetes in Adults  

Oleh:

Brophy, Sinead ; Yderstræde, Knud ; Mauricio, Didac ; Hunter, Stephen ; Hawa, Mohammed ; and Others

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Diabetes Care vol. 31 no. 03 (Mar. 2008), page 439.
Topik: GADA; GAD antibody ; LADA; latent autoimmune diabetes

Ketersediaan

Perpustakaan FK Nomor Panggil: D05.K.2008.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

OBJECTIVE—Latent autoimmune diabetes in adults is type 1 diabetes presenting as non–insulin dependent diabetes. One feature of the selection criteria is time independent of insulin treatment. We examine the validity of this criterion. RESEARCH DESIGN AND METHODS—Patients were recruited in nine European centers, and clinicians reported on criteria for initiating insulin. All patients were tested for GAD antibodies (GADAs) in a central laboratory. We examined time to insulin treatment for GADA-positive patients in six participating centers. RESULTS—There was intercenter variation in the criteria used to initiate insulin. Median time to insulin was 16.15 months (interqartile range 6.7–25.5) in centers with GADA testing compared with 45.6 months (29.5–61.8) in centers without routine GADA testing (P < 0.002). CONCLUSION—Time to insulin should not be used to define patients with LADA because it is dependent on local clinical judgment and the use of laboratory tests for GADA.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali