Identifikasi protein imunogenik Chlamydia pneumoniae terhadap serum penderita infark miokard akut  

Oleh:

Murwani, Sri ; Hidayati, Dwi Yuni Nur

Jenis: Article from Journal - ilmiah nasional
Dalam koleksi: Jurnal Kedokteran Brawijaya vol. 23 no. 02 (Aug. 2007), page 100.
Topik: C. pneumoniae; immunogenic; AMI

Ketersediaan

Perpustakaan FK Nomor Panggil: J34.K.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Chlamydia pneumoniae is human respiratory tract pathogen and recently investigated as pathogen causing atherosclerosis and acute myocardial infarction (AMI). This research was carrier out to detect protein pattern of C. pneumoniae, and to study it relation to AMI through detection of immunogenic protein. Design reserach was laboratory observational and analysed descriptively. the subject was C. pneumoniae. Protein pattern the bacteria was detected by electrophoresis methods, and to detect the immunogenic protein was done immunoblotting. serum was obtain from AMI patients in Saiful Anwar and Lavallete hospitals. The result showed, Protein pattern C. pneumoniae was protein with molecular weight 117, 107, 97, 91, 86, 61, 58, 82, 46, 44, 34, 23, 19, 9, 5, 4 kDa. Immunogenic proteins vary between AMI patients was 117, 107, 86, 61, 568, 52, 46, 44, 64 kDa. non immunogenic proteins were 97, 91, 23, 19, 9, 5, and 4 kDa. Protein 61 kDa react to all of patient's serum. It was concluded, C. pneumoniae have protein fractions 117, 107, 97, 91, 86, 61, 58, 52, 46, 44, 34, 23, 19, 9, 5, and 4 kDa. Immunogenic proteins vary between AMI patients was 117, 107, 86, 61, 58, 52, 46, 44, 34 kDa, and 61 kDa was the immunodominant protein. The result proved C. pneumoniae as causative agent of atherosclerosis and acute myocardial infarction, in indonesia particularly.

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