Maternal n–3, n–6, and trans fatty acid profile early in pregnancy and term birth weight: a prospective cohort study  

Oleh:

Eijsden, Manon van ; Hornstra, Gerard ; Wal, Marcel F. van der ; Vrijkotte, Tanja G.M. ; Bonsel, Gouke J.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The American Journal of Clinical Nutrition vol. 87 no. 04 (Apr. 2008), page 887.

Ketersediaan

Perpustakaan FK Nomor Panggil: A07.K.2008.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Background: Maternal n–3, n–6, and trans fatty acids are claimed to affect fetal growth, yet evidence is limited. Objective: We investigated the association between maternal n–3, n–6, and trans fatty acids measured early in pregnancy and fetal growth. Design: Amsterdam pregnant women (n = 12 373) were invited to complete a questionnaire (response 67%) and donate blood around the 12th pregnancy week for nutrient analysis. For 4336 women, fatty acid concentrations were measured in plasma phospholipids (gas-liquid chromatography). Associations of these concentrations with birth weight and small-for-gestational-age (SGA) risk were analyzed (liveborn singleton term deliveries, n = 3704). Results: Low concentrations of individual n–3 fatty acids and 20:3n–6, the precursor of arachidonic acid (20:4n–6), but high concentrations of the other n–6 fatty acids and the main dietary trans fatty acid (18:1n–9t) were associated with lower birth weight (estimated difference in univariate analysis –52 to –172 g for extreme quintile compared with middle quintile). In general, SGA risk increased accordingly. After adjustment for physiologic, lifestyle-related and sociodemographic factors, low concentrations of most n–3 fatty acids and 20:3n–6 and high concentrations of 20:4n–6 remained associated with lower birth weight (–52 to –57 g), higher SGA risk, or both (odds ratios: 1.38–1.50). Infants of the 7% of women with the most adverse fatty acid profile were on average 125 g lighter and twice as likely to be small for gestational age. Conclusion: An adverse maternal fatty acid profile early in pregnancy is associated with reduced fetal growth, which, if confirmed, gives perspective for the dietary prevention of lower birth weight.

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