Mono Sodium Glutamat (MSG) sebagai Eksitotoksik.  

Oleh:

Susanto, Karim

Jenis: Article from Journal - ilmiah nasional - tidak terakreditasi DIKTI - atma jaya
Dalam koleksi: Majalah Kedokteran Damianus vol. 07 no. 02 (May 2008), page 106-110.
Topik: MSG; Neurotoksik; Neuron Hipotalamus;

Ketersediaan

Perpustakaan PKPM Nomor Panggil: M61 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada	Lihat Detail Induk
Perpustakaan FK Nomor Panggil: D01.K.2008.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada	Lihat Detail Induk

Isi artikel

Monosodium Glutamate (MSG) is sodium salt with glutamate acid is an amino acid component. MSG is a synthetic food additive and is used as a daily additive preservatif. In some of MSG research, they using animals with a high dose MSG and was given per os, parenteral and intra peritoneal. As a result, glutamate was an exitoxic (neurotoxic). In our population, MSG is used as a food additive and to be used for a long period, there is an assumption that it will be accumulated in our body. The study was carried out to imdocate whether there are disturbances on the hypothalamic neuron of the new born mice (Rattus rattus) whose mother were given MSG orally during gestation. THe control group (Group I). Groups terated with 20 X 120 mg/kg BW/day (maximum dose) (Group II), 40 X 120 mg/kg BW/day (Group III), 80 X 120 mg/kgBW/ day (Group IV). Qualitative result : 1. Microscopic Examination : cell edema and picnotic of neural hypothalamic nuclei around third ventricle in Group III and IV. 2. There is a significant correlation between dose and damages. Higher doses makes higher damaged degree.

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