Symposium on Equipoise and the Ethics of Clinical Trials  

Oleh:

Miller, Franklin G. ; Veatch, Robert M.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Journal of Medicine and Philosophy vol. 32 no. 2 (Mar. 2007), page 77-78.
Topik: Symposium; Equipoise; Clinical Trials
Fulltext: MM80V32N2P77.pdf (44.96KB)

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: MM80.17 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Randomized controlled trials (RCTs) are generally considered to be the best method of evaluating the effectiveness of medical treatments. As in all research involving human subjects, RCTs pose an inherent tension between pursuing socially valuable knowledge and protecting research participants. In addition, they face the ethical challenge known as “the RCT dilemma”: How is it possible for physicians to offer optimal, or competent, medical care to patients in need of treatment while conducting scientific experiments that select treatments randomly? The leading, widely endorsed, answer to this question is the doctrine of “clinical equipoise,” developed in 1987 by Benjamin Freedman. According to this doctrine, RCTs are ethical when there is a state of uncertainty in the medical community regarding the therapeutic merit of the investigational treatment and control interventions being evaluated, such that no patient is randomized to a treatment known to be inferior to the established standard of medical care.

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