Beda Efek Pemberian Epinefrin Akut dan Kronis terhadap MCV pada Tikus Putih Jantan  

Oleh:

Agustina R.M. ; Wardani, Tjitra ; Setiawan, Sunarko

Jenis: Article from Journal - ilmiah nasional - tidak terakreditasi DIKTI
Dalam koleksi: Majalah Ilmu Faal Indonesia vol. 06 no. 01 (Oct. 2006), page 23.
Topik: epinephrine; MCV; acute; chronic

Ketersediaan

Perpustakaan FK Nomor Panggil: M07.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

The effect of acute and chronic epinephrine administration on MCV, remains controversial. Physiological approach is needed to investigated epinephrine's effect on erythrocyte quality. The analysis unit was blood taken directly from heart and subjected to MCV (fl). Tratment groups recieved epinephrine subcutaneous injection, and control groups recieved 0.9% NaCl subcutaneous injection. Data were taken directly after one injection (treatment 1), 30 menutes after 1 injection (treatment 2), and after 7 days with 6 injection/days (treatment 3). Epinephrine dose was 0.05 mg/200 gr BW rats in each injection, and injection volume was 0.5 ml. Result obtained in pretest was 53.29 +/- 1.394 Fl. Treatment group with data taken directly after one onjection had 54.73 +/- 1.396 fl, and control was 54.3 +/- 0.839 fl. Tratment group with data taken 30 minutes after injection had 58 +/- 0.759 fl and control 56.1 +/- 1.25 fl. Treatment group receiving 6 times injection/days from which data were taken after 7 days had 52.64 +/- 1.225 fl and the control was 52,2 +/- 0,545 fl. The results of t-test between the delta of pretest and posttest group from which data were taken directly didn't show difference (p=0.98), after 30 minutes show difference (p=0.00), and in group receiving 6 times/day injection for 7 days didn't show difference (p=0.54). Anova test between the delta of treatment and control group showed significant difference (Hotelling's trace, p=0.00). In conclusion : Acute epinefrine data taken 30 minutes after injection may increasing MCV, while acute epinephrine data taken directly and chronic administration didn't show change MCV.

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