Non alcoholic fatty liver disease  

Oleh:

Nurman, A. ; Huang, Margareta A.

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI - non-atma jaya
Dalam koleksi: Universa Medicina vol. 26 no. 04 (Oct. 2007), page 205.
Topik: fatty liver; abdominal obesity; diabetes type 2

Ketersediaan

Perpustakaan FK Nomor Panggil: U01.K.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

The cilinicopathologic spectrum of non alcoholic fatty liver disease (NAFLD) ranges from simple steatosis to non alcoholoic steatohepatitis (NASH) .Simple steatosis has a relatively benign cilinical course,but NASH can progress to cirrhosis and hepatocellular carcinoma. NAFLD is often asymptomatic and its presence must always be considered in patients with abdominal obesity and type 2 diabetes mellitus. Elevation of serum alanin aminotransferase (ALT) level and/or fatty liver appearance on ultrasound are often the 1st clues toward the diagnostic of NAFLD. The diagnostic of NAFLD is established after excluding other causes of chronic liver diseases, such as viral hepatitis, alcoholic liver disease, drug-induced liver disease, etc. However, only liver biopsy establishes the definitive diagnosis. ALT elevation usually does not exceed five times upper normal limit. Should ALT elevation exceed five times upper normal limit, other diagnosis must be considered. Management of NAFLD is not solely directed at NAFLD itself, but should focus on improving insulin resistance and related metabolic dearangements as well, which start with life-style modification. Body weight should be reduced gradually by diet and exercise, as exercise increase glucose uptake in skeletal muscle cells. Vitamine E and ursodeoxylate acid are often administrated due to their economical cost and capable of reducing ALT level, eventhough histological improvement may not always take place. Metformin and/or rosiglitazone can be given to patients without overt diabetes as these drugs do not cause hypoglycemia but improve insulin sensitivity. Avoiding hepatotoxic agents is necessary to prevent further deterioration of liver function.

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