Formulasi Tablet Matriks Mukoadhesif Diltiazem Hidroklorida Menggunakan Hidroksi Propil Metil Selulosa dan Carbopol 940  

Oleh:

Sofiah, Siti ; Faizatun ; Riyana, Yulia

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Jurnal Ilmu Kefarmasian Indonesia vol. 05 no. 02 (Sep. 2007), page 53-58.
Topik: mucoadhesive; carbopol 940; hydroxypropyl methyl cellulose; diltiazem hydrochloride; matrix tablet.

Ketersediaan

Perpustakaan FK Nomor Panggil: J27.K.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Diltiazem hydrochloride has a half life of 3-4 hours and a bioavailability of 40%. The influence of a mixture of carbopol 940 and hydroxypropyl methyl cellulose as a mucoadhesive matrix on tablets made by the wet granulation methods, had been determined by the dissolution and "wash off" methods. The result showed that increasing the concentration of carbopol 940 decreased the dissolution rate. The concentration of carbopol 940 and hydroxypropyl methyl cellulose in formula I (0%; 40%), II (5%,35%), III (10%,30%), IV (15%,25%), and V (20%,20%) released respectively 75,99%; 74,08%; 73,07%; 72,04%; and 71,29% diltiazem hydrochloride. The higher the concentration of carbopol 940 in acid solution, the shorter is the mucoadhesive action: 2 hours in formula I and II, and 1 hour in formula III, IV, and V. All of the formukas (pH 7,2) did not show a difference in mucoadhesive duration; after 8 hours, still attached to the mucosa of the small intestines.

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