Effect of dietary n–3 polyunsaturated fatty acids on plasma total and high-molecular-weight adiponectin concentrations in overweight to moderately obese men and women  

Oleh:

Kratz, Mario ; Swarbrick, Michael M. ; Callahan, Holly S. ; Matthys, Colleen C. ; Havel, Peter J. ; Weigle, David S.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The American Journal of Clinical Nutrition vol. 87 no. 02 (Feb. 2008), page 347.
Topik: Adiponectin ; fatty acids ; omega-3 ; n–3 ; diet ; obesity ; overweight ; humans

Ketersediaan

Perpustakaan FK Nomor Panggil: A07.K.2008.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Background:Recent studies indicated that dietary n–3 polyunsaturated fatty acids (PUFAs) increase circulating adiponectin concentrations in rodents. Objective:We aimed to investigate whether a diet rich in n–3 PUFAs increased plasma concentrations of total or high-molecular-weight (HMW) adiponectin in healthy overweight-to-moderately obese men and women. Design:Sixteen women and 10 men with a body mass index (in kg/m2) between 28 and 33 were randomly assigned to consume a diet rich in n–3 PUFAs (3.5% of energy intake) from both plant and marine sources or a control diet (0.5% of energy intake from n–3 PUFAs). For the first 2 wk, these diets were consumed under isocaloric conditions; then followed a 12-wk period of ad libitum consumption that was associated with a moderate loss of 3.5% of body weight in both groups. Total and HMW adiponectin plasma concentrations were measured before and after each diet phase. Results:Plasma fasting adiponectin concentrations did not change during the isocaloric period, but they increased modestly (10%) during the ad libitum period when subjects lost weight [P = 0.009 for time in repeated-measures analysis of variance] and to a similar extent in subjects consuming the control ( ± SD: 0.42 ± 0.69 µg/mL) and n–3 PUFA (0.45 ± 0.85 µg/mL) diets (P = 0.920 for time x treatment interaction). Plasma concentrations of HMW adiponectin did not change significantly during the study. Conclusion:Dietary n–3 PUFAs consumed at levels of 3.5% of energy intake do not significantly increase plasma or HMW adiponectin concentrations in overweight-to-moderately obese healthy men and women over the course of 14 wk.

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