Low Serum Angiogenin Concentrations in Patients With Type 2 Diabetes  

Oleh:

Siebert, Janusz ; Reiwer-Gostomska, Magdalena ; Babiska, Zofia ; Myliwska, Jolanta ; and Others

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Diabetes Care vol. 30 no. 12 (Dec. 2007), page 3086.
Topik: SIA; serum-induced angiogenesis

Ketersediaan

Perpustakaan FK Nomor Panggil: D05.K.2007.04 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

INTRODUCTION Premature development of microvascular and macrovascular disease is the most frequent complication of diabetes. It is responsible for diabetic retinopathy, nephropathy, and neuropathy (1). Moreover, diabetes leads to reduced collateralization in ischemic tissues, which causes impaired wound healing, exacerbation of peripheral limb ischemia, and a three- to fourfold increase in cardiac mortality in comparison with nondiabetic patients (2,3). The pathophysiological mechanisms responsible for impaired angiogenic activity in diabetes remain unknown. Although angiogenesis impairment has been attributed to alterations in the gene regulatory network, which can be involved in the physiological revascularization process, the role of angiogenin in this process has not been clarified (2,4). The aim of this study therefore was to compare angiogenin serum levels in healthy and type 2 diabetic age-matched individuals. The cutaneous angiogenesis in vivo (serum-induced angiogenesis [SIA]) test in mice was performed in parallel to determine the functional differences between the groups examined. RESEARCH DESIGN AND METHODS A total of 43 patients with type 2 diabetes and 43 age-matched healthy control subjects volunteered for the study. Patients suffering from acute and chronic infections and neoplastic diseases were excluded. Diabetes was defined according to American Diabetes Association criteria (5). All patients had blood glucose . . .

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