Pregnancy-Associated Plasma Protein-A Levels Are Related to Glycemic Control but Not to Lipid Profile or Hemostatic Parameters in Type 2 Diabetes  

Oleh:

Pellitero, Silvia ; Reverter, Jordi L. ; Pizarro, Eduarda ; Pastor, Maria Cruz ; and Others

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Diabetes Care vol. 30 no. 12 (Dec. 2007), page 3083.
Topik: ABI; ankle-brachial pressure index • hsCRP; high-sensitivity C-reactive protein • IL; interleukin • PAPP-A; pregnancy-associated plasma protein-A • TNF; tumor necrosis factor

Ketersediaan

Perpustakaan FK Nomor Panggil: D05.K.2007.04 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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INTRODUCTION Pregnancy-associated plasma protein-A (PAPP-A) is a zinc-binding matrix metalloproteinase that regulates extracellular matrix remodeling. PAPP-A degrades IGFBP-4, increasing levels of local IGF-1 in response to injury, and could be involved in the pathogenesis of atherosclerosis (1–6). Inflammatory cytokines tumor necrosis factor (TNF)- and interleukin (IL)-1ß, implicated in insulin resistance (7), are potent stimulators of PAPP-A (8,9). The association between PAPP-A levels and metabolic parameters such as cholesterol and high-sensitivity C-reactive protein (hsCRP) is controversial (2,10,11). We aimed to study the relationship between PAPP-A, glycemic control and other metabolic and hemostatic parameters, inflammatory cytokines, and ankle-brachial pressure index (ABI) in diabetic patients. RESEARCH DESIGN AND METHODS Type 2 diabetic patients (n = 175, 65 of whom were women) with stable glycemic control (variation in A1C <10% in the last 5 years) and without diagnosis of clinical macrovascular disease, inflammatory disease, malignancies, or pregnancy were studied. Fifty-three (20 of whom were women) nondiabetic subjects without previous clinical macrovascular disease and normal ABI (0.9) were recruited as control subjects. Demographic, anthropometric, and clinical data and ABI were recorded in all subjects. Laboratory data were measured by commercially available assays, hsCRP by nephelometry, ultrasensitive PAPP-A using an enzyme-linked immunosorbent assay, . . .

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