Impaired Postprandial Blood Flow in Adipose Tissue May Be an Early Marker of Insulin Resistance in Type 2 Diabetes  

Oleh:

Dimitriadis, George ; Lambadiari, Vaia ; Mitrou, Panayota ; Maratou, Eirini ; Boutati, Eleni

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Diabetes Care vol. 30 no. 12 (Dec. 2007), page 3128.
Topik: ATBF; adipose tissue blood flow • IGT; impaired glucose tolerance • ISI; insulin sensitivity index • NEFA; nonesterified fatty acids

Ketersediaan

Perpustakaan FK Nomor Panggil: D05.K.2007.04 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

OBJECTIVE—We investigated the changes in subcutaneous adipose tissue blood flow (ATBF) after a meal in the various stages of type 2 diabetes. RESEARCH DESIGN AND METHODS—Five groups were examined: healthy control subjects, first-degree relatives of subjects with type 2 diabetes, subjects with impaired glucose tolerance (IGT), subjects with type 2 diabetes and postprandial hyperglycemia but normal fasting plasma glucose levels (diabetes group A [DMA]), and subjects with type 2 diabetes with both postprandial and fasting hyperglycemia (diabetes group B [DMB]). ATBF was measured with 133Xe. RESULTS—ATBF was higher in control subjects (1,507 ± 103 ml/100 cm3 tissue x min) versus relatives and IGT, DMA, and DMB subjects (845 ± 123, 679 ± 69, 765 ± 60, and 757 ± 69 ml/100 cm3 tissue x min, respectively; P < 0.001). Insulin sensitivity index (ISI) in control subjects (82 ± 3 mg x l2/mmol x mU x min) was higher versus that for relatives and IGT, DMA, and DMB subjects (60 ± 3, 45 ± 1, 40 ± 6, and 29 ± 4 mg x l2/mmol x mU x min, respectively; P < 0.0001). ISI was positively associated with peak-baseline ATBF (ß coefficient 0.029 ± 0.013, P = 0.03). CONCLUSIONS—After meal ingestion, insulin-stimulated ATBF was decreased in relatives and and IGT, DMA, and DMB subjects. This defect could be an early marker of insulin resistance that precedes the development of type 2 diabetes.

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