Corticosteroids in Septic Shock  

Oleh:

Finfer, Simon

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The New England Journal of Medicine (keterangan: ada di Proquest) vol. 358 no. 02 (Jan. 2008), page 188.

Ketersediaan

Perpustakaan FK Nomor Panggil: N08.K.2008.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

As the balance of evidence regarding corticosteroid treatment for septic shock shifts once again toward the negative, the study by Sprung et al.1 in this issue of the Journal elicits a strong feeling of déjà vu. Will the historical fate of high-dose corticosteroids, which were largely abandoned when the benefit observed in early studies could not be replicated in larger trials,2,3 now befall "physiologic-dose" corticosteroids? The rationale for therapy with corticosteroids at a physiologic dose (i.e., 200 to 300 mg of hydrocortisone per day) originated in the observations that patients with septic shock who had a reduced response to corticotropin . . .

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