Type 2 Diabetes Without the Atherogenic Metabolic Triad Does Not Predict Angiographically Assessed Coronary Artery Disease in Women  

Oleh:

Blackburn, Patricia ; Lemieux, Isabelle ; Lamarche, Benoit ; Bergeron, Jean ; Perron, Patrice ; Tremblay, Gérald ; Gaudet, Daniel ; Despres, Jean-Pierre

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Diabetes Care vol. 31 no. 01 (Jan. 2008), page 170.

Ketersediaan

Perpustakaan FK Nomor Panggil: D05.K.2008.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Evidence suggests that the coronary heart disease (CHD) risk of type 2 diabetes is heterogeneous and affected by the presence/absence of the metabolic syndrome (1). We have previously reported that specific features of the metabolic syndrome (atherogenic metabolic triad) were associated with a 20-fold increase in the risk of developing CHD (2). Considering the costs and lack of standardization of these indexes in clinical practice, we have suggested that the simultaneous measurement and interpretation of waist circumference and fasting triglyceride levels were useful in identifying individuals with the atherogenic metabolic triad and therefore at increased risk for coronary artery disease (CAD) (3). The main objective of the present study was to compare the risk of CAD between nondiabetic and type 2 diabetic women with/without features of the atherogenic metabolic triad. RESEARCH DESIGN AND METHODS This cross-sectional study was conducted in a sample of 250 women (56.2 ± 9.1 years) who underwent an angiographic procedure for the investigation of retrosternal pain. Subjects were French Canadians of European origin (Caucasians). Inform written consent was obtained and the study approved by the Chicoutimi Hospital Ethics Committee. CAD was assessed by angiography (4). Anthropometric measurements were performed following standardized techniques (5). Fasting lipid profile, glycemia, and LDL particle size (6–8) were determined according to routine methods. Homeostasis model assessment was used . . .

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