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ArtikelA ß-Defensin Mutation Causes Black Coat Color in Domestic Dogs  
Oleh: Candille, Sophie I. ; Kaelin, Christopher B. ; Cattanach, Bruce M. ; Bin, Yu ; Thompson, Darren A. ; Nix, Matthew A. ; Kerns, Julie A. ; Schmutz, Sheila M. ; Millhauser, Glenn L. ; Barsh, Gregory S.
Jenis: Article from Bulletin/Magazine
Dalam koleksi: SCIENCE (keterangan: ada di Proquest) vol. 318 no. 5855 (Nov. 2007), page 1418.
Ketersediaan
  • Perpustakaan FK
    • Nomor Panggil: S01.K.2007.09
    • Non-tandon: 1 (dapat dipinjam: 0)
    • Tandon: tidak ada
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Isi artikelGenetic analysis of mammalian color variation has provided fundamental insight into human biology and disease. In most vertebrates, two key genes, Agouti and Melanocortin 1 receptor (Mc1r), encode a ligand-receptor system that controls pigment type-switching, but in domestic dogs, a third gene is implicated, the K locus, whose genetic characteristics predict a previously unrecognized component of the melanocortin pathway. We identify the K locus as ß-defensin 103 (CBD103) and show that its protein product binds with high affinity to the Mc1r and has a simple and strong effect on pigment type-switching in domestic dogs and transgenic mice. These results expand the functional role of ß-defensins, a protein family previously implicated in innate immunity, and identify an additional class of ligands for signaling through melanocortin receptors.
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