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A ß-Defensin Mutation Causes Black Coat Color in Domestic Dogs
Oleh:
Candille, Sophie I.
;
Kaelin, Christopher B.
;
Cattanach, Bruce M.
;
Bin, Yu
;
Thompson, Darren A.
;
Nix, Matthew A.
;
Kerns, Julie A.
;
Schmutz, Sheila M.
;
Millhauser, Glenn L.
;
Barsh, Gregory S.
Jenis:
Article from Bulletin/Magazine
Dalam koleksi:
SCIENCE (keterangan: ada di Proquest) vol. 318 no. 5855 (Nov. 2007)
,
page 1418.
Ketersediaan
Perpustakaan FK
Nomor Panggil:
S01.K.2007.09
Non-tandon:
1 (dapat dipinjam: 0)
Tandon:
tidak ada
Lihat Detail Induk
Isi artikel
Genetic analysis of mammalian color variation has provided fundamental insight into human biology and disease. In most vertebrates, two key genes, Agouti and Melanocortin 1 receptor (Mc1r), encode a ligand-receptor system that controls pigment type-switching, but in domestic dogs, a third gene is implicated, the K locus, whose genetic characteristics predict a previously unrecognized component of the melanocortin pathway. We identify the K locus as ß-defensin 103 (CBD103) and show that its protein product binds with high affinity to the Mc1r and has a simple and strong effect on pigment type-switching in domestic dogs and transgenic mice. These results expand the functional role of ß-defensins, a protein family previously implicated in innate immunity, and identify an additional class of ligands for signaling through melanocortin receptors.
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