Penghambatan Oksidasi dan Akumulasi Kolesterol pada Mirofag oleh Ekstrak Temulawak (Curcuma xanthorriza Roxb)  

Oleh:

Septiana, Aisyah Tri ; Dwiyanti, Hidayah ; Muchtadi, Deddy ; Zakaria, Fransiska

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Jurnal Teknologi dan Industri Pangan vol. 17 no. 3 (Dec. 2006), page 221.
Topik: Low density lipoprotein; macrophage; cholesterol; temulawak; Curcuma xanthorriza Roxb

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: TT33 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Coronary heart disease is caused among others by atherosclerosis, which is the result of oxidized low density lipoprotein (LDL) and cholesterol accumulation on the macrophage. This were reported to be inhibited by temulawak (Curcuma xanthorizza Roxb). The objective ofthis study was to find out the types and consentrations of temulawak extract which could inhibit LDL oxidation, and to find out the effect of temulawak extract on the accumulation of cholesterol on macrophage. Temulawak was extracted by water, ethanol, aceton and dichlorometane. Inhibition of LDL oxidation was analyzed by measuring the level of malonaldehyde content of the oxidized LDL-CUSO4 which were given water extract, ethanol extract, aceton extract and dichlorometane extract. oftemulawak at concentrations of 43 pg, 430 and 4300 ,ug per ml of LDL. The percentage of malonaldehyde reduction due to addition of water, ethanol, acetone and dich/oromethane extract were 44.27; 47.68; 51.83 and 61.2 respectively. The inhibition of LDL oxidation by temulawak extract depends on the concentrations. The percentage of ma/onaldehyde reduction due to addition of temulawak extract of43 pg, 430pg, and 4300 pg per ml of LDL were 43.63; 56.72; and 53.89 Concentrations oftemulawak extract resulting in the highest inhibition of LDL oxidation was 430 pg/ml LDL. Temulawak extract tends to inhibit cholesterol accumulation on the macrophage. There is a correlation between the inhibition ofcholesterol accumulation on the macrophage and the inhibition ofLDL oxidation by temulawak extract.

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