Cases in Primary Care Laboratory Medicine : Macrocytosis: pitfalls in testing and summary of guidance  

Oleh:

Galloway, Michael ; Hamilton, Malcolm

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: British Medical Journal (keterangan: ada di Proquest) vol. 335 no. 7625 (Oct. 2007), page 884.

Ketersediaan

Perpustakaan FK Nomor Panggil: B16.K.2007.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Summary points Macrocytosis is commonly associated with the use of several drugs and does not require further investigation unless there are additional clinical features Before testing, the probability of vitamin-B12 or folate deficiency should be undertaken by assessing relevant features in the history and examination Myelodysplastic syndromes often present as a macrocytic anaemia with normal vitamin-B12 and folate concentrations When full blood count is normal, vitamin-B12 deficiency should be suspected in patients with neurological signs and severe oropharyngeal ulceration Deficiency of vitamin B-12 and folate classically causes a macrocytic anaemia, but macrocytosis may be due to causes other than deficiency of vitamin B-12 and folate. Neurological changes due to vitamin B-12 deficiency may develop in the absence of changes in the blood count. Incorrect interpretation of vitamin B-12 levels in particular can lead to a wrong diagnosis, inappropriate referral to hospital, and inappropriate investigation. We have published guidance on the indications for . . .

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