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ArtikelComparison of the effects of fish and fish-oil capsules on the n–3 fatty acid content of blood cells and plasma phospholipids  
Oleh: Harris, William S. ; Pottala, James V. ; Sands, Scott A ; Jones, Philip G.
Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The American Journal of Clinical Nutrition vol. 86 no. 06 (Dec. 2007), page 1621.
Topik: n–3 Fatty acids ; eicosapentaenoic acid ; docosahexaenoic acid ; fish ; fish oil ; erythrocytes ; phospholipids
Ketersediaan
  • Perpustakaan FK
    • Nomor Panggil: A07.K.2007.04
    • Non-tandon: 1 (dapat dipinjam: 0)
    • Tandon: tidak ada
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Isi artikelBackground: n–3 Fatty acids (FAs) have been shown to be beneficial for cardiovascular health. Whether n–3 FAs from oily fish consumed weekly or from fish-oil capsules taken daily are equally bioavailable is not clear. Objective: The purpose of this study was to compare the rate and extent of enrichment of blood cell membranes [ie, red blood cells (RBCs)] and plasma phospholipids with n–3 FAs from these 2 sources. Design: Healthy premenopausal female volunteers were randomly assigned to consume a daily average of 485 mg eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids either from 2 servings of oily fish (ie, salmon and albacore tuna) per week or from 1–2 capsules/d. Results: After 16 wk, EPA+DHA in RBCs in the fish group (n = 11) increased from 4.0 ± 0.6% of total FAs to 6.2 ± 1.4%, whereas it rose from 4.3 ± 1.0% to 6.2 ± 1.4% in the capsule group (P < 0.0001 for both; NS for group effect). Similar results were observed in plasma phospholipids. EPA+DHA stabilized in the latter after 4 wk but continued to rise through week 16 in RBCs. EPA in RBCs increased significantly (P = 0.01) more rapidly in the fish group than in the capsule group during the first 4 wk, but rates did not differ significantly between groups thereafter. Total FA variances were less in RBCs than in plasma phospholipids (P = 0.04). Conclusion: These findings suggest that the consumption of equal amounts of EPA and DHA from oily fish on a weekly basis or from fish-oil capsules on a daily basis is equally effective at enriching blood lipids with n–3 FAs.
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