Serum retinol-binding protein 4 concentrations in response to short-term overfeeding in normal-weight, overweight, and obese men  

Oleh:

Shea, Jennifer ; Randell, Edward ; Vasdev, Sudesh ; Wang, Peizhong Peter ; Roebothan, Barbara ; Guang, Sun

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The American Journal of Clinical Nutrition vol. 86 no. 05 (Nov. 2007), page 1310.
Topik: Retinol-binding protein 4 ; overfeeding ; adiposity status ; young men ; insulin resistance ; lipids

Ketersediaan

Perpustakaan FK Nomor Panggil: A07.K.2007.04 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Background: Retinol-binding protein 4 (RBP4) is a novel adipokine that induces insulin resistance in mice. Studies in humans have shown a correlation between serum RBP4 and insulin resistance in obese subjects and in subjects with type 2 diabetes. Few data are available regarding the nutritional regulation of RBP4. Objective: The study investigated the relation of RBP4 with phenotypes of glucose and lipid metabolism at baseline and in response to a 7-d overfeeding protocol in young men. Design: Sixty-five men participated in the study. Subjects were classified on the basis of body mass index (BMI; kg/m2) as normal-weight (24.9) or as overweight or obese (25.0). Serum RBP4, interleukin-6, visfatin, glucose, insulin, total cholesterol, HDL cholesterol, and LDL cholesterol (calculated), and triacylglycerols were measured. Insulin resistance and ß cell function were assessed by using the homeostasis model. Percentage body fat was measured by using dual-energy X-ray absorptiometry. Results: No significant differences were found in serum RBP4 between the 2 groups at baseline. Likewise, no significant differences were observed in fasting serum RBP4 in response to overfeeding. Baseline RBP4 was negatively correlated with the change in insulin resistance in normal-weight subjects, independent of age and BMI. No significant correlation was found between serum RBP4 and visfatin, interleukin-6, or any other variables measured. Conclusions: Short-term overfeeding did not induce significant changes in RBP4. Baseline RBP4 concentrations may predict insulin resistance when exposed to a positive energy challenge in normal-weight men.

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