Interactions of Child Maltreatment and Serotonin Transporter and Monoamine Oxidase a Polymorphisms: Depressive Symptomatology among Adolescents from Low Socioeconomic Status Backgrounds  

Oleh:

Rogosch, Fred A. ; Cicchetti, Dante ; Sturge-Apple, Melissa L.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Development and Psychopathology vol. 19 no. 4 (2007), page 1161–1180.
Topik: serotonin transporter
Fulltext: 1161.pdf (466.7KB)

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Perpustakaan Pusat (Semanggi) Nomor Panggil: DD21.13 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Child maltreatment and polymorphisms of the serotonin transporter (5-HTT) and monoamine oxidase A (MAOA) genes were examined in relation to depressive symptomatology. Adolescents (M age ¼ 16.7 years) from low socioeconomic backgrounds with a history of child maltreatment (n ¼ 207) or no such history (n ¼ 132) were interviewed and provided buccal cells for genetic analysis. Geneenvironment interactions were observed. Heightened depressive symptoms were found only among extensively maltreated youth with low MAOA activity. Among comparably maltreated youth with high MAOA activity, self-coping strategies related to lower symptoms. Sexual abuse and the 5-HTT short/short genotype predicted higher depression, anxiety, and somatic symptoms. This GeneEnvironment interaction was further moderated by MAOA activity level. The results highlight the protective functions of genetic polymorphisms and coping strategies in high risk youth and offer direction for understanding resilience and its promotion from a multiple levels of analysis perspective.

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