Gene–Environment Interactions Reexamined: Does Mother's Marital Stability Interact with the Dopamine Receptor D2 Gene in the Etiology of Childhood Attention-Deficit/Hyperactivity Disorder?  

Oleh:

Waldman, Irwin D.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Development and Psychopathology vol. 19 no. 4 (2007), page 1117–1128.
Fulltext: 1117.pdf (111.57KB)

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: DD21.13 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Potential candidate GeneEnvironment interactions in the etiology of childhood attention-deficit/hyperactivity disorder (ADHD) are examined between the dopamine receptor D2 gene (DRD2) and putative family environmental risk factors that reflect mothers’ marital stability. Specifically, interactions were tested between DRD2 and mothers’ marital status, number of marriages or cohabiting relationships, and age at first marriage. Moderate relations were found among the marital stability measures, and mother’s marital status and number of marriages or cohabiting relationships (but not age at first marriage) were risk factors for their children’s ADHD. All three mother’s marital stability variables were associated with either the child’s or mother’s DRD2 genotypes. GeneEnvironment interactions were found for children’s ADHD diagnoses between children’s DRD2 genotypes and mother’s marital status and number of marriages or cohabiting relationships. It is of interest that these interactions were strengthened with the progressive addition of sets of covariates intended to control for alternative causal pathways that represent background genetic and environmental context confounds. The present findings highlight the importance of considering both the nexus of putative environmental risk factors and whether their etiology and effects are truly environmental in future GeneEnvironment interaction research.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali