Gene x Environment Interactions In Speech Sound Disorder Predict Language And Preliteracy Outcomes  

Oleh:

Smith, Shelley D. ; Shriberg, Lawrence D. ; Boada, Richard ; McGrath, Lauren M. ; Pennington, Bruce F. ; Willcutt, Erik G.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Development and Psychopathology vol. 19 no. 4 (2007), page 1047-1072.
Topik: Preliteracy Outcomes; Predict Language; Environment Interactions; Gene
Fulltext: 1047.pdf (814.2KB)

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: DD21.13 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Few student have investigated the role of gene X environment interaction (G xE) in speech, language, and literacy disorders. Currently, there are two theoritical models, the diathesis stress and the bioecological model, that make opposite predictions about the expected direction of GxE, because environmental risk factors may either strengthen or weaken the effect of genes on phenotypes. The purpose of the current study was to test for G x E a two speech sound disorder and reading disability linkage peaks using a sib-pair linkage design and continous measures of socioeconomic status, home language, and literacy environment, and number of ear infections. The interactions were tested using composite speech, language, pleliteracy phenotypes and previously identified linkage peaks on 6p22 and 15p21. Result showed five G x E at both the 6p22 and 15p21 locations across severall phenotypes and environmental measures. Four of the five interactions were consistent with the bioecological model of G x E. Each of these four interactions involved environmental measures of the home language/ literacy environment. The only interaction that was consistent with the diathesis stress model was one involving the number of ear infections as the environmental risk variable. The direction of these interactions and possible interpretations are explored in the discussion.

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