Genetic Expression Outside The Skin: Clues to Mechanism of Genotype x Environment Interaction  

Oleh:

Leve, Leslie D. ; Reiss, David

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Development and Psychopathology vol. 19 no. 4 (2007), page 1005-1027.
Topik: Environment Interaction; Mechanism of Genotype; Genetic Expression
Fulltext: 1005.pdf (340.6KB)

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: DD21.13 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

The rapidly moving study of Gene x Environment interaction (GxE) needs interim conceptual tool to track progress, integrate findings, and apply this knowledge to preventive intervention. We define two closely related concepts: the social mediation of the expression of genetic influencesand the interaction between the entire genotype and the social mediation of the expession of genetic influences and the interaction between the entire genotype and the social environment (GxE). GxE, the primary focus of this report, assesses individual differences in the full genotype using twin, sbling, and adoption designs and, for the most part, emplyos fine-grained analyses of relational processes in the social environment. In comparison, studies of Allele x Environment interaction assess the influence on development of one or more measured polymorphism as modified by environmental factors. GxE studies build on work showing how the social environment responds the genetic influences shape the social environment. Recent GxE research has yielded new insight into variations in the sensitivity of the social environmental responses that can be leveraged to inform preventive interventions aimed at reducing genetic risk for problem behaviour.

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