Association Between The Recombinant Human Serotonin Transporter Linked Protoer Region Polymorphism ad Behaviour in Rhesus Macaques During a Separation Paradigm  

Oleh:

Spinelli, Simona ; Schwandt, Melanie L. ; Lindell, Stephen G. ; Newman, Timothy K. ; Heilig, Markus ; Suomi, Stephen J. ; Higley, J. Dee ; Goldman, David ; Barr, Christina S.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Development and Psychopathology vol. 19 no. 4 (2007), page 977–987.
Topik: Separation paradigm; Rhesus Macaques; Protoer Region Polymorphism ad Behaviour
Fulltext: 977.pdf (110.37KB)

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Perpustakaan Pusat (Semanggi) Nomor Panggil: DD21.13 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Human studies have suggested an assosiation between a variable length polymorphism in the serotonin transporter gene promoter region and vulnerability to anxiety and depression. Relative to the long (l) allele, the sort (s) allele increases the risk of developing depression in individuals exposed to stressful life events. An orthologue of the human variant is present in rhesus macaques and allows for studies in animals exposed to stress. Here, we used an established model of early life stress exposure, in which rhesus macaques are raised without adults in a group of peers (peer-only reared [PR]), or with their mothers. At 6 months of age, animals were subjected to 4 day long social separations for 4 consecutive week, with 3 days of reunion in between. Data were collected during both the scute (Day 1) and cronic phase despair, agitation, and behavioural factors generated were despair and behavioral pathology and, for the chronic phases (Day 2-4) of separaton. Behavioral factors were separately extraced for each phase of separation. For acute separation, the behavioral factors generated were despair and behavioral pathology and, for the chronic phase despair, agitation, and behavioral pathology. During both phases of social separation, PR l/s animals were more likely to exhibit pathological behaviours, whereas PR l/l monkeys show higher levels of despair compared to the other three groups. These fndings indicate that early stress affects the behavioural response to separation differently as a function of recombinant human serotonin transporter linked polymorphic repeat genotype and suggest that carrier of the s allele are not only more anxious but may also be more vulnerable to developing behavioral pathology in the face of chronic adversity.

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