Biometric and developmental Gene-environment Interactions: Looking Back, Moving Forward  

Oleh:

Tabery, James

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Development and Psychopathology vol. 19 no. 4 (2007), page 961-976.
Topik: Biometric and developmental Gene-environmen Interactions
Fulltext: 961.pdf (433.39KB)

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Perpustakaan Pusat (Semanggi) Nomor Panggil: DD21.13 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

A history of research on gene-environmentinteraction (GxE) is provided in this article, revealing the fact that there have actually been two distinct concepts of GxE since the very origins of this research. R. A. Fisher introduced what I call the biometric concept of GxE (GxEb), whereas Lancelot Hogben introduced what I call the developmental concept of GxE (GxEd). Much of the subsequent history research on GxE has largely consisted of the separate legacies of these separate concepts, along with the (sometimes acrimonious) dispute that have arisen time and again when employers of each have argued over the appropriate way to conceptualize the phenomenon. With this history in place, more recent attempts to distinguish between different concepts of GxE are considered, paying particular attention to the commonly made distiction between "statistical interaction" and "interactionism," and Michael Rutter's distiction between statistical interaction and "the biological concept of interaction." I argue that the history of the separate legacies of GxEb and GxEd better supports Rutter's analysis of the situation and that this analysis best paves the way for an integrative relationship between the various scientists investigating the place of GxE in the etiology of complex traits.

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