Epilepsy in pregnancy  

Oleh:

Tomson, Torbjorn ; Hiilesmaa, Vilho

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: British Medical Journal (keterangan: ada di Proquest) vol. 335 no. 7623 (Oct. 2007), page 769.

Ketersediaan

Perpustakaan FK Nomor Panggil: B16.K.2007.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

This article explores the therapeutic problems that arise when a patient with epilepsy on treatment becomes pregnant and needs both effective seizure control and attention to the safety of her fetus Introduction Scenario A 33 year old woman had had occasional myoclonic jerks in the mornings since the age of 15, usually after sleep deprivation. Two years later, after her first generalised tonic-clonic seizure, she was diagnosed with juvenile myoclonic epilepsy, an idiopathic generalised epilepsy. After her second tonic-clonic seizure she was prescribed valproate. During the next two years, she had a few more tonic-clonic seizures until the dosage of valproate was increased to 500 mg twice daily. On this medication, she was free from seizures for 11 years and only had isolated myoclonic jerks—years apart—always after sleep deprivation. Two years ago, her medication was changed from valproate to lamotrigine in response to her plans for pregnancy and the concern that valproate could be teratogenic. This conversion was uneventful. She has remained free from tonic-clonic seizures, but her myoclonic jerks have been slightly more frequent despite a lamotrigine dose of 150 mg twice . . .

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