Cadherin 23 and protocadherin 15 interact to form tip-link filaments in sensory hair cells  

Oleh:

Kazmierczak, Piotr ; Hirofumi Sakaguchi ; Tokita, Joshua ; Wilson-Kubalek, Elizabeth M. ; Milligan, Ronald A. ; Muller, Ulrich ; Kachar, Barbara

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: NATURE (keterangan: ada di Proquest) vol. 449 no. 7158 (Sep. 2007), page 87.

Ketersediaan

Perpustakaan FK Nomor Panggil: N01.K.2007.09 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Hair cells of the inner ear are so-called because of the hair-like projections, or stereocilia, that protrude from their apical surface. Sound-induced stereocilial motion is thought to be coupled to mechanoelectrical transduction channels via the 'tip links' that connect stereocilia to one another. Kazmierczak et al. now report the composition of mammalian tip links. They are formed by the interaction of two members of the family of calcium-dependent cell adhesion proteins, cadherin and protocadherin 15. Interestingly, mutation of these cadherins causes deafness in humans and one such mutation disrupts the interaction between the two molecules. .

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