Obesity and overweight in relation to mortality in men with and Without Type 2 Diabetes/Impaired Glucose Tolerance : The original Whitehall Study  

Oleh:

Batty, G. David ; Kivimaki, Mika ; Smith, George Davey ; Marmot, Michael G. ; Shipley, Martin J.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Diabetes Care vol. 30 no. 09 (Sep. 2007), page 2388.
Topik: CVD; cardiovascular disease ; CHD; coronary heart disease ; IGT; impaired glucose tolerance

Ketersediaan

Perpustakaan FK Nomor Panggil: D05.K.2007.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

In studies of apparently healthy individuals, overweight and obesity, typically assessed using BMI, have been consistently associated with an increased risk of all-cause mortality, cardiovascular disease (CVD), and select cancers (1–4). However, extrapolating these results to individuals with type 2 diabetes is complex and perhaps inappropriate. Studies of the influence of obesity and overweight on mortality risk in individuals with type 2 diabetes reveal highly inconsistent findings. With all-cause mortality, obesity shows inverse (5,6), positive (7–10), null (11–16), and "J-" or "U-" shaped (17–19) associations; similarly discrepant results are apparent with coronary heart disease (CHD) (10,12,20,21). This discordance may be at least partially explained by methodological limitations in some studies, such as a modest sample size, a differential categorization of weight across studies, a tendency not to separate diabetes into its two main subtypes, and a failure to adjust for potentially important mediating and confounding variables. Using an extended follow-up of a U.K. prospective cohort study, we addressed this paucity of evidence and methodological shortcomings.....

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