Variation of the Transcription Factor 7-Like 2 (TCF7L2) Gene Predicts Impaired Fasting Glucose in Healthy Young Adults  

Oleh:

Raitakari, Olli T. ; Ronnemma, Tapani ; Huupponen, Risto ; Viikari, Liisa ; Meng, Fan ; and Others

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Diabetes Care vol. 30 no. 09 (Sep. 2007), page 2299.
Topik: IFG; impaired fasting glucose ; HOMA; homeostasis model assessment ; HOMA-B; HOMA for ß-cell function ; HOMA-IR; HOMA for insulin resistance ; SNP; single nucleotide polymorphism

Ketersediaan

Perpustakaan FK Nomor Panggil: D05.K.2007.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Recently, Grant et al. (1) reported an association between type 2 diabetes and variation in the transcription factor 7-like 2 (TCF7L2) gene. Thereafter, the relation has been replicated in several populations (2–11). The mechanisms by which TCF7L2 variants contribute to the development of type 2 diabetes are incompletely understood. To gain insight on potential mechanisms, we examined the effects of TCF7L2 on the incidence of impaired fasting glucose (IFG) in young adults....

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