Tonsillectomy and Adenoidectomy Are Not Associated With an Altered Risk of Childhood-Onset Type 1 Diabetes  

Oleh:

Cardwell, Chris R. ; Carson, Dennis J. ; McNaboe, Edward J. ; Patterson, Chris C.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Diabetes Care vol. 30 no. 10 (Oct. 2007), page 2564.
Topik: Tonsillectomy and Adenoidectomy Are Not Associated With an Altered Risk of Childhood-Onset Type 1 Diabetes

Ketersediaan

Perpustakaan FK Nomor Panggil: D05.K.2007.04 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Type 1 diabetes results from the autoimmune destruction of the pancreatic ß-cells. As various studies have shown that tonsillectomy and adenoidectomy, particularly in childhood, impact the function of the immune system (1), it is possible that these procedures could increase a child’s risk of type 1 diabetes. Conversely, the hygiene hypothesis (2) suggests that frequent exposure to infections in early life may protect against type 1 diabetes. Therefore, children undergoing tonsillectomy and adenoidectomy may be expected to have a reduced risk of type 1 diabetes because they are likely to have experienced higher rates of respiratory and ear infections in early childhood than other children. Previously, a Finnish case-control study (3) of type 1 diabetes with adenoidectomy reported a modest though not significant increase in the risk of diabetes, while a possible association with tonsillectomy has been investigated only in a small Canadian case-control study (4). The aim of this study was to investigate, for the first time in a cohort setting, the risk of type 1 diabetes after tonsillectomy and/or adenoidectomy in children identified from hospital records.....

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