Parental History and Risk of Type 2 Diabetes in Overweight Latino Adolescents : A longitudinal analysis  

Oleh:

Kelly, Louise A. ; Lane, Christianne J. ; Weigensberg, Marc J. ; Koebnick, Corinna ; Roberts, Christian K. ; Davis, Jaimie N. ; Toledo-Corral, Claudia M. ; Shaibi, Gabriel Q. ; Goran, Michael I.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Diabetes Care vol. 30 no. 10 (Oct. 2007), page 2700.
Topik: FSIVGTT; frequently sampled intravenous glucose tolerance test ; mtDNA; mitochondrial DNA ; OGTT; oral glucose tolerance test

Ketersediaan

Perpustakaan FK Nomor Panggil: D05.K.2007.04 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

OBJECTIVE— The purpose of this article was to examine metabolic risk factors for type 2 diabetes in children and adolescents as a function of maternal versus paternal family history of type 2 diabetes and to examine whether differences in these risk factors emerge during adolescent growth. RESEARCH DESIGN AND METHODS— A total of 247 overweight Latino children (baseline age = 11.1 ± 1.7 years) with a parental history of type 2 diabetes were followed annually for 5 years (2.2 ± 1.2 observations/child) with measures of insulin sensitivity, acute insulin response to glucose, and disposition index. Longitudinal linear mixed-effects modeling was used to evaluate the influence of maternal versus paternal family history of type 2 diabetes on changes in diabetes risk factors over age. RESULTS— Insulin sensitivity and the disposition index decreased over age (ß = –0.052 and ß = –0.033, P < 0 0.01). Acute insulin response to glucose and fasting and 2-h glucose increased (ß = 0.019, ß = 0.002, and ß = 0.003, P < 0.01). Declines in insulin sensitivity were significantly greater in participants whose maternal grandmothers had a history of type 2 diabetes (ß = –0.03, P = 0.03). Declines in the disposition index (ß = –0.02, P = 0.04) and increases in fasting glucose were significantly influenced by a maternal history of type 2 diabetes (ß = 0.60, P < 0.05). CONCLUSIONS— Maternal but not paternal family history for diabetes may have a significant impact on insulin dynamics, becoming more pronounced during growth in overweight Latino adolescents. Further research is clearly warranted.

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