Conjugated linoleic acid supplementation alters the 6-mo change in fat oxidation during sleep  

Oleh:

Close, Rachel N ; Schoeller, Dale A. ; Watras, Abigail C. ; Nora, Elizabeth H.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The American Journal of Clinical Nutrition vol. 86 no. 03 (Sep. 2007), page 797.
Topik: Energy expenditure ; fat oxidation ; substrate utilization ; overweight ; obesity treatment

Ketersediaan

Perpustakaan FK Nomor Panggil: A07.K.2007.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Background: Conjugated linoleic acid (CLA) is a family of positional and geometric isomers with 2 conjugated double bonds formed from linoleic acid and linolenic acid. CLA has a wide range of biological effects, including body fat reduction. Objective: The aim of our study was to determine CLA's effects on energy expenditure, macronutrient utilization, and dietary fat oxidation in overweight adults after 6 mo of supplementation. Design: We recruited 23 subjects from our main CLA efficacy study who were receiving either 4 g/d of 78% active CLA isomers (3.2 g/d: 39.2% cis-9,trans-11 and 38.5% trans-10,cis-12) or 4 g/d of safflower oil. Energy expenditure and substrate utilization were measured before and after 6 mo of CLA supplementation by using whole-room indirect calorimetry. Dietary fat oxidation was measured by using stable isotope–labeled oleate and palmitate. Results: Our substudy detected a difference in the change in fat utilization between the CLA (4 ± 8 g) and placebo (–7 ± 11 g) groups during sleep after 6 mo of supplementation. In addition, the percentage of energy from protein was reduced during sleep in the CLA group (CLA: –3.3 ± 2.6%; placebo: 0.3 ± 5.7%). We also detected a difference in the change in energy expenditure during sleep (CLA: 0 ± 38 kcal; placebo: –43 ± 90 kcal). We did not detect a change in labeled dietary fat oxidation after 6 mo of CLA supplementation given with a breakfast meal. Conclusion: Mixed isomer CLA supplementation, but not placebo, positively altered fat oxidation and energy expenditure during sleep.

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