THE ACCURACY OF RADIOCOllOID AND BLUE DYE METHODS IN DETECTING SENTINEL NODE IN THE EARLY STAGE Of BREAST CANCER  

Oleh:

Yueniwati, Yuyun ; Yulisa, N. Diana ; Iskandar, Arief

Jenis: Article from Journal - ilmiah nasional
Dalam koleksi: Jurnal Kedokteran Brawijaya vol. 23 no. 01 (Apr. 2007), page 29.
Topik: radiocolloid; blue dye; sentinel node; breast cancer

Ketersediaan

Perpustakaan FK Nomor Panggil: J34.K.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Breast cancer incidence varies in many countries but in general increases. This research aimed to find out the accuracy of radiocolloid (Iymphoscintigraphy and gamma probe) as well as blue dye method in detecting sentinel node in the early stage breast cancer. Diagnostic examination was conducted on 163 nodes of 14 patients cross sectionally, comparing the accuracy of radiocolloid and blue dye methods with histopathologic method as the gold standard. Subject characteristics were female, aged 39-53, mostly menopause, multipara and breast-feeding. Primary tumors were mostly found in the right, upper lateral quadrant, T2, histopathologic results showed that all were of invasive ductal carcinomas and 71.4% cases were lymphatic emboli. The detection of sentinel node with Iymphoscintigraphy had 81.8% accuracy, sensitivity 90.4%, specificity 73.2%, NPV 98.1%, false-negative 1.8% and kappa value 0.37. Detection using gamma probe resulted in 79% accuracy, sensitivity 90.4%, specificity 67.6%, NPV 97.9%, false-negative 2% and kappa value 0.31. When both were conducted, it had 83.6% accuracy, sensitivity 90.4%, specificity 76.8%, NPV 98.2%, false-negative 1.8% and kappa value 0.56. Fourteen percen sentinel node were internal mammary nodfJ. The accuracy of blue dye method cannot be calculated in this research, detection rate was 71.4%. It is concluded that radiocolloid method has high accuracy and suitability in detecting sentinel node in the early stage of breast cancer, and can be applied for early detection in conjunction with Sentinel Lymph Node Biopsy (SLNB).

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