Anda belum login :: 23 Jul 2025 05:01 WIB
Home
|
Logon
Hidden
»
Administration
»
Collection Detail
Detail
The Relationship Between Adrenomedullin, Metabolic Factors, and Vascular Function in Individuals With Type 2 Diabetes
Oleh:
Su, Chi Lim
;
Morgenthaler, Nils G.
;
Subramaniam, Tavintharan
;
Yew, Seng Wu
;
Siew, Kheng Goh
;
Chee Fang Sum
Jenis:
Article from Journal - ilmiah internasional
Dalam koleksi:
Diabetes Care vol. 30 no. 06 (Jun. 2007)
,
page 1513.
Topik:
Pathophysiology
;
Complications
Ketersediaan
Perpustakaan FK
Nomor Panggil:
D05.K.2007.02
Non-tandon:
1 (dapat dipinjam: 0)
Tandon:
tidak ada
Lihat Detail Induk
Isi artikel
OBJECTIVE—Subjects with type 2 diabetes are at risk for vascular injury. Several vasoactive factors (e.g., angiotensin) have been implicated. We hypothesize that adrenomedullin, a novel vascoactive factor, is deranged in subjects with type 2 diabetes. RESEARCH DESIGN AND METHODS—Using a new immunoluminometric method, plasma midregional proadrenomedullin (MR-proADM) was measured in four groups of Chinese subjects: healthy (n = 100, fasting plasma glucose [FPG] <5.6 mmol/l), impaired fasting glucose (IFG) (n = 60, FPG 5.6–6.9 mmol/l), and diabetic subjects with (n = 100) and without (n = 100) nephropathy. Resting forearm cutaneous microcirculatory perfusion (RCMP) was quantified in vivo using 2-dimensional laser Doppler flowmetry. We investigated the relationship between plasma MR-proADM concentrations, multiple metabolic factors, and vascular function. RESULTS—We observed a stepwise increase in MR-proADM among the groups: healthy group mean ± SD 0.27 ± 0.09, IFG group 0.29 ± 0.13, diabetic group 0.42 ± 0.13, and diabetic nephropathy group 0.81 ± 0.54 nmol/l (diabetic vs. healthy and IFG groups, P = 0.04; and diabetic nephropathy group vs. all, P < 0.01). Statistical adjustment for sex, age, BMI, and blood pressure did not affect the conclusions. Multiple linear regression analysis revealed that highly sensitive C-reactive protein (ß = 0.11; P = 0.01), insulin resistance index (ß = 0.20; P = 0.001), LDL cholesterol (ß = 0.31; P < 0.001), and adiponectin (ß = 0.33; P < 0.001) were significant predictors of plasma MR-proADM concentrations among nondiabetic individuals. Among subjects with diabetes, plasma MR-proADM concentrations correlated significantly with RCMP (r = 0.43, P = 0.002). CONCLUSIONS—Plasma MR-proADM concentration was elevated in subjects with type 2 diabetes. This was further accentuated when nephropathy set in. MR-proADM was related to multiple metabolic factors and basal microcirculatory perfusion. Adrenomedullin might play a role in the pathogenesis of diabetic vasculopathy.
Opini Anda
Klik untuk menuliskan opini Anda tentang koleksi ini!
Kembali
Process time: 0 second(s)