Methods for a Multisite Randomized Trial to Investigate the Effect of Constraint-Induced Movement Therapy in Improving Upper Extremity Function among Adults Recovering from a Cerebrovascular Stroke  

Oleh:

Winstein, Carolee J. ; Miller, J. Philip ; Blanton, Sarah ; Taub, Edward ; Uswatte, Gitendra ; Morris, David ; Nichols, Deborah ; Wolf, Steven

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Neurorehabilitation and Neural Repair vol. 17 no. 3 (Sep. 2003), page 137-152.
Topik: RCT; rehabilitation; stroke interventionsupper extremity; motor recovery; behavior.
Fulltext: 137NNR173.pdf (126.35KB)

Isi artikel

This article describes the study design, methodological considerations, and demographic characteristics of a phase III RCT to determine if 1) constraint-induced therapy (CI therapy) can be applied with therapeutic success 3 to 9 months after stroke across different sites, 2) gains that might occur persist over 2 years, 3) initial level of motor ability determines responsiveness to CI therapy, and 4) the treatment effect differs between those treated before 9 months and after 1 year. Six sites will screen and recruit poststroke survivors stratified on initial level of motor ability and after randomization allocate participants to immediate or delayed intervention. Primary outcomes include a laboratory-based measure of function (Wolf Motor Function Test [WMFT]) and a real-world participant- centered functional use measure (Motor Activity Log [MAL]). Secondary outcomes concern function, behavior, and compliance. This is the first multisite, single- blind RCT of a formal training intervention for upper extremity rehabilitation in subacute stroke in the United States.

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