Sex DiRerences in Endothelial Function Markers Before Conversion to Pre-Diabetes: Does the Clock Start Ticking Earlier Among Women?  

Oleh:

Donahue, Richard P. ; Rejman, Karol ; Rafalson, Lisa B. ; Dmochowskl, Jacek ; Stranges, Saverio ; Trevisan, Maurizio

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Diabetes Care vol. 30 no. 02 (Feb. 2007), page 354.

Ketersediaan

Perpustakaan FK Nomor Panggil: D05.K.2007.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

OBJECTIVE - We examined whether biomarkers of endothelial function, fibrinolysis/ thrombosis and adiponectin, predict the progression from normal to pre-diabetes more strongly among women than men over 6 years of follow-up from the Western New York Health Study. RESEARCH DESIGN AND METHODS- In 2002-2004,1,455 participants from the Western New York Health Study, who were free of type 2 diabetes and cardiovascular disease at baseline (1996-2001), were selected for reexamination. An incident case of pre-diabetes was defined as fasting glucose <100 mgldl at the baseline examination and ~100 and < 126 mgldl at the follow-up examination. Biomarkers of endothelial function (E-selectin and soluble intracellular adhesion molecule-l [sICAM-I]), fibrinolysis/thrombosis (plasminogen activator inhibitor-I [PAl-I]), and fasting insulin, adiponectin, and inflammation (high-sensitivity C-reactive protein) were measured in frozen ( -190°C) baseline samples. RESULTS - Multivariate analyses revealed higher adjusted mean values of biomarkers of endothelial dysfunction (E-selectin and sICAM-I) and fibrinolysis (PAI-l) and lower mean values of adiponectin only among women who developed pre-diabetes compared with control subjects. Formal tests for interaction between sex and case/control status were statistically significant for E-selectin (P = 0.042), PAI-I (P = 0.00l), sICAM-I (P = 0.011), and frequency of hypertension (P < 0.00l). CONCLUSIONS - These results support the concept that women who progressed from normoglycemia to pre-diabetes have greater endothelial dysfunction than men as well as more hypertension and a greater degree of fibrinolysis/thrombosis. Whether this relates to the higher risk of heart disease among diabetic women awaits further study.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali