High Risk of Cardiovascular Mortality in Individuals With Impaired Fasting Glucose Is Explained by Conversion to Diabetes  

Oleh:

Rijkelijkhuizen, Josina M. ; Nijpels, Giel ; Heine, Robert J. ; Bouter, Lex M ; Stehouwer, Coen D.A. ; Dekker, Jacqueline M.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Diabetes Care vol. 30 no. 02 (Feb. 2007), page 332.

Ketersediaan

Perpustakaan FK Nomor Panggil: D05.K.2007.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

OBJECTIVE - To optimize identification of future diabetic patients, the American Diabetes Association (ADA) introduced criteria for impaired fasting glucose (IFG) in 1997 (IFG 6.1 mmol/I [IFG6.1]) and lowered the threshold from 6.1 to 5.6 mmol/I (IFG5.6) in 2003. Our aim was to assess the consequences of lowering the lFG cutoff on the risk of cardiovascular disease (CVD) mortality and to evaluate whether this risk is explained by a conversion to type 2 diabetes within 6.4 years. RESEARCH DESIGN AND METHODS - In a population-based cohort, the Hoom Study, plasma glucose was determined in 1989 and 1996 (n = 1,428). Subjects were classified in 19B9 according to 1997 and Lt)t)j A!>A crIteria. ~ubJeds w1\:h iFti In Ws'9 were iurther classified according to diabetes status in 1996. Hazard ratios for CVD mortality (n = 81) in the period 1996-2005 were adjusted for age and sex. RESULTS- Subjects with lFG6.1, but not lFG5.6, had a significantly higher CVD mortality risk than normal fasting glucose (NFG) subjects. Subjects who converted from lFG to diabetes (IFG6.1: 42%; lFG5.6: 21%) had a more than twofold risk of CVD mortality (IFG6.1: 2.47 [1.17-5.19]; lFG5.6: 2.14 [1.12-4.10]) than subjects with NFG. lFG subjects who did not develop diabetes did not have significantly higher CVD mortality risks (IFG6.1: 1.50 [0.723.15]; lFG5.6: 1.15 [0.69-1.93]). CONCLUSIONS - The lower cutoff for lFG (ADA 2003 criteria) results in a category ofIFG that no longer represents a high-risk state of CVD. Furthermore, only subjects who convert from lFG to diabetes have a high risk of CVD mortality.

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