Prevalence of Candida glabrata and Its Response to Boric Acid Vaginal Suppositories in Comparison With Oral Fluconazole in Patients With Diabetes and Vulvovaginal Candidiasis  

Oleh:

Ray, Debarti ; Goswami, Ravinder ; Banerjee, Uma ; Dadhwal, Vatsla ; Goswami, Deepti ; Mandal, Piyali ; Sreenivas, Vishnubhatla ; Kochupillai, Narayana

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Diabetes Care vol. 30 no. 02 (Feb. 2007), page 312.

Ketersediaan

Perpustakaan FK Nomor Panggil: D05.K.2007.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

OBJECTIVE - A large proportion of vulvovaginal candidiasis (We) in diabetes is due to non-albicans Candida species such as C. glabrata and C. tropicalis. Observational studies indicate that diabetic patients with C. glabrata we respond poorly to azole drugs. We evaluated the response to oral fluconazole and boric acid vaginal suppositories in diabetic patients with we. RESEARCH DESIGN AND METHODS - A total of 112 consecutive diabetic patients with we were block randomized to receive either single-dose oral 150-mg fluconazole or boric acid vaginal suppositories (600 mg/day for 14 days). The primary efficacy outcome was the mycological cure in patients with C. glabrata we in the two treatment arms. The secondary outcomes were the mycological cure in C. albicans we, overall mycological cure irrespective of the type of Candida species, frequencies of yeast on direct microscopy, and clinical symptoms and signs of we on the 15th day of treatment. Intention-to-treat (ITT; n = 111) and perprotocol (PP; n = 99) analyses were performed. RESULTS - C. glabrata was isolated in 68 (61.3%) and C. albicans in 32 (28.8%) of III subjects. Patients with C. glabrata we showed higher mycological cure with boric acid compared with fluconazole in the ITT (21 of 33, 63.6% vs. 10 of 35, 28.6%; P = 0.01) and PP analyses (21 of29, 72.4% vs. 10 of 30,33.3%; P = 0.01). The secondary efficacy outcomes were not significantly different in the two treatment arms in the ITT and PP analyses. CONCLUSIONS - Diabetic women with C. glabrata we show higher mycological cure with boric acid vaginal suppositories given for 14 days in comparison with single-dose oral 150-mg fluconazole.

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