A novel test for simultaneous measurement of pancreatic J3-cell function, insulin sensitivity, and glucose tolerance  

Oleh:

Hansen, Torben ; Drivsholm, Thomas ; Urhammer, Soren A. ; Palacios, Rene T. ; Volund, Aage ; Borch-Johnsen, Knut ; Pedersen, Oluf

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Diabetes Care vol. 30 no. 02 (Feb. 2007), page 257.

Ketersediaan

Perpustakaan FK Nomor Panggil: D05.K.2007.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

OBJECTIVE - Insulin resistance and impaired j3-cell function are key elements in the patho!enesis of type 2 diabetes. We aimed to develop valid algorithms for estimation of the insulin sensuIVity index (5j) and acute insulin response (AIR) derived from simple and cheap physiological measurements that could be used in large-scale metabolic, genetic, and epidemiological studies. RESEARCH DESIGN AND METHODS - For our purpose, data from an oral glucose tolerance test (OGTT) (18 samples during 240 min) and a tolbutamide-modified intravenous 'JklJSe'tolerance test (IVGTT) (33 samples during 180 min) from 258 individuals with fasting plasma glucose <7 mmol/l and 2-h plasma glucose <7.8 mmol/l were used for model development and internal validation. Data from an additional 28 individuals were used for external validation. Bergman's minimal model was used to calculate 5j, and the trapezoidal method was used to calculate AIRo-8 min' Multiple linear regression was applied to derive predictive equations of log(5j) and log(AIRo-8 min) using data on sex, BMI, plasma glucose, and serum insulin levels obtained during the OGTT. RESULTS - We demonstrate that it is possible to obtain estimates of 5j (BIGTT -5j) and AIR (BlGTT -AIR) that are highly correlated to IVGTT -derived values of 5j (R2 = 0.77) and AIR (R2 = 0.54). In the two validation datasets we obtained similar results. CONCLUSIONS - Data from OGTTs can provide accurate measures of insulin sensitivity and cell function, which can be used in large scale metabolic, genetic, and epidemiological studies.

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