Serum Adi,onectin and Renal Dysfunction In Men With Type 2 Diabetes  

Oleh:

Lin, Julie ; Hu, Frank B. ; Curhan, Gary

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Diabetes Care vol. 30 no. 02 (Feb. 2007), page 239.

Ketersediaan

Perpustakaan FK Nomor Panggil: D05.K.2007.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

OBJECTIVE - Inflammation is associated with both chronic kidney dysfunction and type 2 ~labetes. Adiponectin, a novel circulating anti-inflammatory protein made by adipocytes, has been reported to be lower in diabetic than nondiabetic subjects. In contrast, serum levels of adiponectin are elevated in end -stage renal disease. We sought to investigate the relation between adlponectin and mild to moderate renal dysfunction in men with type 2 diabetes. RESEARCH DESIGN AND METHODS - Multivariate logistic regression was used to evaluate the relation between serum adiponectin concentrations and the presence of renal dysfunction (estimated glomerular filtration rate [eGFR] <60 ml/min per 1. 73 m2 by the fourvariable Modification of Diet in Renal Disease equation) in participants with type 2 diabetes in the Health Professionals' Follow-Up Study. A total of 733 men were included in this cross sectional analysis. RESULTS - Adiponectin was positively correlated with age (Spearman coefficient, r = 0.19, P< 0.001) and negatively correlated with weight (Spearman coefficient, r = -0.18, P < 0.001). Those with adiponectin in the second quartile or higher (> 10 fLglml) compared with those in the first quartile had a reduced odds for renal dysfunction (multivariate odds ratio 0.48 [95% Cl 0.28-0.81]). These results were unchanged when serum lipids were included in the multivariate model. CONCLUSIONS - We conclude that a higher serum adiponectin concentration is associated with reduced odds of moderate renal dysfunction in men with type 2 diabetes.

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