Progression From Newly Acquired Impaired Fasting Glusose to Type 2 Diabetes  

Oleh:

Nichols, Gregory A. ; Hillier, Teresa A ; Brown, Jonathan B.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Diabetes Care vol. 30 no. 02 (Feb. 2007), page 228.

Ketersediaan

Perpustakaan FK Nomor Panggil: D05.K.2007.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

OBJECTIVE - We sought to estimate the rate of progression from newly acquired (incident) impaired fasting glucose (IF G) to diabetes under the old and new IFG criteria and to identify predictors of progression to diabetes. RESEARCH DESIGN AND METHODS - We identified 5,452 members of an HMO with no prior history of diabetes, with at least two elevated fasting glucose tests (I 00-125 mgldl) measured between 1 January 1994 and 31 December 2003, and with a normal fasting glucose test before the two elevated tests. All data were obtained from electronic records of routine clinical care. Subjects were followed until they developed diabetes, died, left the health plan, or until 31 December 200S. RESULTS- Overall, 8.1 % of subjects whose initial abnormal fasting glucose was 100-109 mgldl (added IFG subjects) and 24.3% of subjects whose initial abnormal fasting glucose was 110-125 mgldl (originallFG subjects) developed diabetes (P < 0.0001). Added IFG subjects who progressed to diabetes did so within a mean of 41.4 months, a rate of 1.34% per year. OriginallFG subjects converted at a rate of 5.56% per year after an average of 29.0 months. A steeper rate of increasing fasting glucose; higher BM1, blood pressure, and triglycerides; and lower HDL cholesterol predicted diabetes development. CONCLUSIONS - To our knowledge, these are the first estimates of diabetes incidence from a clinical care setting when the date of IFG onset is approximately known under the new criterion for IFG. The older criterion was more predictive of diabetes development. Many newly identified IFG patients progress to diabetes in <3 years, which is the currently recommended screening interval

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