Effect of Adiunctive Pramlintide Treatment on Treatment Satisfaction in Patients With Type I Diabetes  

Oleh:

Marrero, David G. ; Crean, John ; Zhang, Bei ; Kellmeyer, Terrie ; Gloster, Maurice ; Herrmann, Kathrin ; Rubin, Richard ; Fineberg, Naomi ; Kolterman, Orville

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Diabetes Care vol. 30 no. 02 (Feb. 2007), page 210.

Ketersediaan

Perpustakaan FK Nomor Panggil: D05.K.2007.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

OBJECTIVE - To assess the effect of adjunctive pramlintide treatment on treatment satisfaction in patients with type 1 diabetes treated with intensive insulin regimens. RESEARCH DESIGN AND METHODS - Intensively treated (multiple daily injection [MOl] or continuous subcutaneous insulin infusion [CSII] pump therapy) patients with type 1 diabetes completed a study-specific treatment satisfaction questionnaire following 29 weeks of either placebo (n = 136) or pramlintide (n = 130) treatment in a double-blind, noninferiority pramlintide dose titration trial. End points included patient reponed outcomes, their relationship to insulin treatment regimen, AIC, weight, and insulin use. RESULTS - Pramlintide-treated patients reponed greater treatment satisfaction in most questionnaire responses. Treatment satisfaction was similar for pramlintide-treated patients regardless of intensive insulin regimens (MOl versus CSII). Mean AIC was reduced to a similar degree in both pramlintide- (-0.39 :!:: 0.07%) and placebo-treated (-0.45 :!:: 0.07%) patients. However, pramlintide treatment was associated with reductions in mean body weight (-1.50 :!:: 0.33 kg; P < 0.0001) and mealtime insulin use (-19.05 :!:: 5.17%; P < 0.005) over 29 weeks, while placebo treatment resulted in weight gain 0.28 :!:: 0.25 kg) and a smaller reduction in mealtime insulin use (- 2.20 :!:: 3.33%). CONCLUSIONS - Despite similar reductions in AIC, pramlintide treatment resulted in greater treatment satisfaction compared with placebo treatment. This was independent of insulin delivery method.

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