Detail Epigenetic Decisions in Mammalian Germ Cells   Oleh:  Schaefer, Christopher B. ; Ooi, Steen K.T. ; Bestor, Timothy H ; Bourc'his, Deborah Jenis: Article from Bulletin/Magazine Dalam koleksi: SCIENCE (keterangan: ada di Proquest) vol. 316 no. 5823 (Apr. 2007), page 398. Topik: Germ Cell Ketersediaan Perpustakaan FK Nomor Panggil: S01.K.2007.04 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada     Lihat Detail Induk Isi artikel Speccific sequences are designated for de novo DNA methylation at CpG dinucleotides in mammalian germ cells. The result is the long-term transcriptional silencing of the methylated sequences, most of which are retrotransposons and CpG-rich sequences associated with imprinted genes. There is profound sexual dimorphism in both the nature of the sequences that undergo de novo methylation is regulated. The restriction of future gene expression by the imposition of heritable methylation patterns in germ cell genomes is characteristic of mammals but is rare in other taxa. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Kembali

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