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Germ Cell Specification in Mice
Oleh:
Hayashi, Katsuhiko
;
Lopes, Susan M. Chuva De Sousa
;
Surani, M. Azim
Jenis:
Article from Bulletin/Magazine
Dalam koleksi:
SCIENCE (keterangan: ada di Proquest) vol. 316 no. 5823 (Apr. 2007)
,
page 394.
Topik:
Germ Cell
Ketersediaan
Perpustakaan FK
Nomor Panggil:
S01.K.2007.04
Non-tandon:
1 (dapat dipinjam: 0)
Tandon:
tidak ada
Lihat Detail Induk
Isi artikel
Specification of germ cells in mice occurs relatively late in embryonic development. it is initiated by signals that induce expression of Blimp1, a key regulator of the germ cell, in a few epiblast cells of early postimplantation embryos. Blimp1 represses the incipient somatic program in these cells and promotes progression toward the germ cell fate. Blimp1 may also have a role in the maintenance of early germ cell characteristics by ensuring their escape from the sometic fate as well as possible reversion to pluripotent stem cells.
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