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ArtikelGerm Cell Specification in Mice  
Oleh: Hayashi, Katsuhiko ; Lopes, Susan M. Chuva De Sousa ; Surani, M. Azim
Jenis: Article from Bulletin/Magazine
Dalam koleksi: SCIENCE (keterangan: ada di Proquest) vol. 316 no. 5823 (Apr. 2007), page 394.
Topik: Germ Cell
Ketersediaan
  • Perpustakaan FK
    • Nomor Panggil: S01.K.2007.04
    • Non-tandon: 1 (dapat dipinjam: 0)
    • Tandon: tidak ada
    Lihat Detail Induk
Isi artikelSpecification of germ cells in mice occurs relatively late in embryonic development. it is initiated by signals that induce expression of Blimp1, a key regulator of the germ cell, in a few epiblast cells of early postimplantation embryos. Blimp1 represses the incipient somatic program in these cells and promotes progression toward the germ cell fate. Blimp1 may also have a role in the maintenance of early germ cell characteristics by ensuring their escape from the sometic fate as well as possible reversion to pluripotent stem cells.
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