Detail Attenuation of Allergic Contact Dermatitis Through the Endocannabinoid System   Oleh:  Karsak, Meliha ; Gaffal, Evelyn ; Date, Rahul ; Wang-Eckhardt, Lhua ; Rehnelt, Jennifer ; Petrosino, Stefania ; Steuder, Regina ; Schlicker, Eberhard ; Cravatt, Benjamin ; Mechoulam, Raphael ; Buettner, Reinhard ; Werner, Sabine ; Di Marzo, Vincenzo ; Tuting, Thomas ; Zimmer, Andreas Jenis: Article from Bulletin/Magazine Dalam koleksi: SCIENCE (keterangan: ada di Proquest) vol. 316 no. 5830 (Jun. 2007), page 1494. Ketersediaan Perpustakaan FK Nomor Panggil: S01.K.2007.06 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada     Lihat Detail Induk Isi artikel Allergic contact dermatitis affects about 5% of men and 11% of women in industrialized countries and is one of the leading causes for occupational diseases. In an animal model for cutaneous contact hypersensitivity, we show that mice lacking both known cannabinoid receptors display exacerbated allergic inflammation. In contrast, fatty acid amide hydrolase-deficient mice, which have increased levels of the endocannabinoid anandamide, displayed reduced allergic responses in the skin. Cannabinoid receptor antagonists exacerbated allergic inflammation, whereas receptor agonists attenuated inflammation. These results demonstrate a protective role of the endocannabinoid system in contact allergy in the skin and suggest a target for therapeutic intervention. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Kembali

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