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Archaeal Type III RuBisCOs Function in a Pathway for AMP Metabolism
Oleh:
Sato, Takaaki
;
Atomi, Haruyuki
;
Imanaka, Tadayuki
Jenis:
Article from Bulletin/Magazine
Dalam koleksi:
SCIENCE (keterangan: ada di Proquest) vol. 315 no. 5814 (Feb. 2007)
,
page 1003.
Ketersediaan
Perpustakaan FK
Nomor Panggil:
S01.K.2007.02
Non-tandon:
1 (dapat dipinjam: 0)
Tandon:
tidak ada
Lihat Detail Induk
Isi artikel
The type III ribulose-l,S-bisphosphate carboxylase-oxygenase (RuBisCO) present in the archaeon Thermococcus kodakaraensis was found to partidpate in adenosine S'-monophosphate (AMP) metabolism, a role that is distinct from that of classical RuBisCOs of the Calvin-Benson-Bassham cycle. Genes annotated as thymidine phosphorylase (deoA) and !!ucaryal translation initiation factor 2B (e2b2) were found to encode AMP phosphorylase and ribose-l,S-bisphosphate isomerase, respectively. These enzymes supplied the RuBisCO substrate, ribulose-l,S-bisphosphate, from AMP and phosphate. Archaea with type III RuBisCOs all harbor both DeoA and the corresponding E2b2 homologs. In this pathway, adenine was released from AMP and the phosphoribose moiety entered central-carbon metabolism
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