Detail Asymmetric T Lymphocyte Division in the Initiation of Adaptive Immune Responses   Oleh:  Chang, John T. ; Palanivel, Vikram R. ; Kinjyo, Ichiko ; Schambach, Felix ; Intlekofer, Andrew M ; Banerjee, Arnob ; Longworth, Sarah A. ; Vinup, Kristine E. ; Mrass, Paul ; Oliaro, Jane ; Kileen, Nigel ; Orange, Jordan S. ; Russell, Sara M. ; Weninger, Wolfgang ; Reiner, Steven L. Jenis: Article from Bulletin/Magazine Dalam koleksi: SCIENCE (keterangan: ada di Proquest) vol. 315 no. 5819 (Mar. 2007), page 1687. Topik: Immunology Ketersediaan Perpustakaan FK Nomor Panggil: S01.K.2007.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada     Lihat Detail Induk Isi artikel A hallmark of mammalian immunity is the heterogeneity of cell fate that exists among pathogen experienced lymphocytes. We show that a dividing T lymphocyte initially responding to a microbE exhibits unequal partitioning of proteins that mediate signaling, cell fate specification, and asymmetric cell division. Asymmetric segregation of determinants appears to be coordinated by prolonged interaction between the T cell and its antigen-presenting cell before division. Additionally, the first two daughter T cells displayed phenotypic and functional indicators of bein~ differentially fated toward effector and memory lineages. These results suggest a mechanism by which a single lymphocyte can apportion diverse cell fates necessary for adaptive immunity. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Kembali

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