Detail An X Chromosome Gene, WTX, Is Commonly Inactivated in Wilms Tumor   Oleh:  Rivera, Miguel N. ; Kim, Woo Jae ; Wells, Julie ; Driscoll, David R. ; Brannigan, Brian W ; Kim, James C. ; Feinberg, Andrew P ; Gerald, William L. ; Vargas, Sara O. ; Chin, Lynda ; John lafrate, A ; Bell, Daphne W ; Haber, Daniel A. Jenis: Article from Bulletin/Magazine Dalam koleksi: SCIENCE (keterangan: ada di Proquest) vol. 315 no. 5812 (Feb. 2007), page 642. Ketersediaan Perpustakaan FK Nomor Panggil: S01.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada     Lihat Detail Induk Isi artikel Wilms tumor is a pediatric kidney cancer associated with inactivation of the WTl tumor-suppressor gene in 5 to 10% of cases. Using a high-resolution screen for DNA copy-number alterations in Wilms tumor, we identified somatic deletions targeting a previously uncharacterized gene on the X chromosome. This gene, which we call WTX, is inactivated in approximately one-third of Wilms tumors (15 of 51 tumors). Tumors with mutations in WTX lack WTl mutations, and both genes share a restricted temporal and spatial expression pattern in normal renal precursors. In contrast to biallelic inactivation of autosomal tumor-suppressor genes, WTX is inactivated by a monoallelic "single-hit" event targeting the single X chromosome in tumors from males and the active X chromosome in tumors from females. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Kembali

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