Detail Anaphase Onset Before Complete DNA Replication with Intact Checkpoint Responses   Oleh:  Torres-Rosell, Jordi ; De Piccoli, Giacomo ; Cordon-Preciado, Violeta ; Farmer, Sarah ; Jarmuz, Adam ; Machin, Felix ; Pasero, Philippe ; Lisby, Michael ; Haber, James E. ; Aragon, Luis Jenis: Article from Bulletin/Magazine Dalam koleksi: SCIENCE (keterangan: ada di Proquest) vol. 315 no. 5817 (Mar. 2007), page 1411. Ketersediaan Perpustakaan FK Nomor Panggil: S01.K.2007.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada     Lihat Detail Induk Isi artikel Cellular checkpoints prevent mitosis in the presence of stalled replication forks. Whether checkpoints also ensure the completion of DNA replication before mitosis is unknown. Here, we show that in yeast smc5-smc6 mutants, which are related to cohesin and condensin, replication is delayed, most significantly at natural replication-impeding loci like the ribosomal DNA gene duster. In the absence of SmcS-Smc6, chromosome nondisjunction occurs as a consequence of mitotic entry with unfinished replication despite intact checkpoint responses. Eliminating processes that obstruct replication fork progression restores the temporal uncoupling between replication and segregation in smc5-smc6 mutants. We propose that the completion of replication is not under the surveillance of known checkpoints. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Kembali

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