Clomiphene, Metformin, or Both for Infertility in the Polycystic Ovary Syndrome  

Oleh:

Legro, Richard S. ; Barnhart, Huiman X ; Schlaff, William D. ; Carr, Bruce R ; Diamond, Michael P. ; Carson, Sandra A ; Steinkampf, Michael P. ; Coutifaris, Christos ; McGovern, Peter G. ; Cataldo, Nicholas A ; Gosman, Gabriella G. ; Nestler, John E. ; Giudice, Linda C ; Leppert, Phyllis C. ; Myers, Evan R.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The New England Journal of Medicine (keterangan: ada di Proquest) vol. 356 no. 06 (Feb. 2007), page 551.

Ketersediaan

Perpustakaan FK Nomor Panggil: N08.K.2007.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

BACKGROUND The polycystic ovary syndrome is a common cause of infertility. Clomiphene and insulin sensitizers are used alone and in combination to induce ovulation, but it is unknown whether one approach is superior. METHODS We randomly assigned 626 infertile women with the polycystic ovary syndrome to receive clomiphene citrate plus placebo, extended-release metformin plus placebo, or a combination of metformin and clomiphene for up to 6 months. Medication was discontinued when pregnancy was confirmed, and subjects were followed until delivery. RESULTS The live-birth rate was 22.5% (47 of 209 subjects) in the clomiphene group, 7.2% (15 of 208) in the metformin group, and 26.8% (56 of 209) in the combinationtherapy group (P

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